4,5 For preparations that will be applied topically, a micronized form of the powder should be used. Progesterone is extensively metabolized by the liver and is not usually given by the oral route, with some exceptions. It is commercially available orally and as a parenteral injection in a suitable solvent. Progesterone is compounded into numerous dosage forms, including topical solutions, creams, gels, transdermal gels, injections, capsules, troches, minitroches, nasal sprays, and others. It melts at about 126☌ to 131☌ and exists as a polymorph that melts at 121☌. Progesterone is a naturally occurring progestin that occurs as a white or creamy white, crystalline powder that is practically insoluble in water, soluble in alcohol, and sparingly soluble in vegetable oils. Flux rates in the system were maintained from 2 to 40 hours in the range of 0.10 to 0.16 mcg/cm 2/hour. The study was conducted over 40 hours with seven sampling times. Formulas tested included VersaBase Cream Cosmetic HRT, a mixture of VersaBase Cream with VersaBase Gel (95:5), and Vanicream. Absorption was measured in human cadaver skin, in vitro, using the finite dose technique and Franz diffusion cells. 3 The study was designed to evaluate the percutaneous absorption pharmacokinetics of progesterone. 3 In a comparison with Vanicream, it delivered more than four times as much progesterone deep into the dermis. This preparation has been studied for its ability to transport progesterone into and through human skin. The formulation used is determined by the physician, patient, and pharmacist-the triad relationship. Compounded BHRT preparations include oral, topical/transdermal, parenteral, and nasal administration implants and others. Numerous single-drug formulas, as well as multiple-drug formulas, are prescribed and compounded. In some instances, dehydroepiandrosterone also is used. 2ĭiscussion: Bioidentical hormone replacement therapy (BHRT) generally includes the hormones progesterone, estradiol, estrone, estriol, and testosterone. Quality Control: Quality-control assessment can include theoretical weight compared with actual weight, apparent pH, specific gravity, active drug assay, color, texture–surface, texture–spatula spread, appearance, feel, rheologic properties, and physical observations. Stability: Check with the manufacturer of the VersaBase Cream for a beyond-use date for this preparation. Use: This preparation has been used in hormone replacement therapy. A dispensing-type container works well for these products after it has been calibrated. Geometrically, incorporate the VersaBase Cream and mix well. Mix the progesterone with the pentylene glycol until the mixture is uniform and smooth. Accurately weigh or measure each ingredient. Method of Preparation: Calculate the quantity of each ingredient for the amount to be prepared.